Update: Need injections? New regulations have made them impossible to find… until now. I partnered up with Oxford Biosciences so we can all get our shots again ;) Read more about the absolute best vitamin B12 supplement.
Almost a century ago, a debilitating, pernicious type of anemia affected people, causing very low red blood cell counts, neurological damage, and eventually death. Doctors were trying hard to find a cure, without success. Until…
One doctor, Dr. George Hoyt Whipple of the University of Rochester, ran an innovative experiment and showed that the administration of liver rapidly regenerated blood counts of dogs he made anemic by bleeding.
From this idea, Drs. William P. Murphy and George R. Minot proposed that liver might be useful in the treatment of the pernicious anemia even though it was different than the anemia induced in Whipple’s dogs. They then started feeding patients with liver, with success so great it awarded them a Nobel prize.
Dr. William Bosworth Castle of Harvard University soon discovered that patients who had stomach surgery still had that anemia despite being fed liver and meat. He then suspected something within the stomach must aid the absorption of whatever was in liver and meat. So he did the only sane thing…
Ate meat, vomited it out, and fed his own vomit to patients.
And it worked! He named whatever it was in stomach juices that aided the absorption of meat, intrinsic factor. The miraculous compound in Drs. Whipple, Murphy and Minot’s liver was called extrinsic factor. Years later, that extrinsic factor was isolated and given its current name…
But what is B12 really? What are the richest sources? How to know if you’re deficient? With vit B12 deficiency so widespread, I now present to you the…
Definitive Guide: What Is Vitamin B12?
What are the best sources of vitamin B12? Which of them would give you the richest dose per meal?
What does vitamin B12 do in your body? What are its primary benefits?
Methylcobalamin vs Cyanocobalamin vs Hydroxycobalamin vs Adenosylcobalamin
What are the causes and symptoms of vitamin B12 deficiency? How do we treat it?
What are the benefits and drawbacks of B12 injections, and should you take these shots?
Can vitamin B12 be toxic in large amounts? Is there any risk of overdosing?
Update: I added a new piece, about optimal B12 levels.