The best vitamin B12 supplement form has always been, and will always be, B12 injections. It’s actually the only solution for people with absorption issues, since it bypasses the gastric route and goes straight to the blood.
The problem is that new regulations regarding purchasing shots online have made B12 injections nearly impossible to find. That wouldn’t be a problem if you could just get them over the counter, but unless you’re from Japan, good luck finding shots from methylcobalamin, the superior form.
Good news, folks!
I teamed up with Oxfords Biosciences to solve that and get you the ultimate vitamin B12 supplement you can get. It’s a vial of 40,000mcg (40mg) pure, tested and high-quality methylcobalamin B12. It’s really awesome.
Our B12 Supplement Benefits:
You don’t need a prescription.
The big problem with those new regulations is that, to get a kit of injections these days, you must schedule a consultation call with a physician and get a prescription. It’s an expensive process, and it takes time.
Technically, our vial is a simple nutritional supplement, not an “injection kit”. We don’t ship it with needles. This makes us able to sell it without you having to go through an expensive consultation call or prescription.
This vial contains 40,000mcg of pure methylcobalamin in powder form, to which you’ll add saline and then inject. The saline and syringes you’ll buy in a pharmacy. Don’t worry, they cost a few dollar only.
Worldwide availability. (Free international shipping!)
Because we’re free of these regulations, you can get the supplement no matter where you are in the world. From India to Scotland to America, the B12 vial will be sent to you through Royal Mail, free of charge.
The B12 injection brand I used to recommend before uses sterile water to dissolve their B12. That’s not the best practice. Methylcobalamin is best absorbed when dissolved in an isotonic solution, meaning saline.
In numerous studies, people reported severe pain injecting B12 dissolved in water, but little to zero pain injecting in saline. It happens because the body is saltier than water, so you get a sharp sting whenever you inject anything in water. I’ll also send you instructions on how to inject subcutaneously (and not intramuscularly), because it’s painless and proven very efficient.
We get the methylcobalamin from a certified, reputable pharmaceutical lab in England. From the lab, it goes straight to Oxford Biosciences to conduct tests and ensure high purity, potency and sterility.
Lasts longer than regular injection kits.
Methylcobalamin can be destroyed if exposed to light when in liquid form. This is why a dry supplement like this is best. You can keep it as powder for until you need it. And when you mix it with saline, you can immediately cover the vial with aluminum foil to block light and prevent destruction.
This is not a retail product, simply a vial of methylcobalamin from a high quality, certified lab. This allows me to sell it for a really low price. Normally, you’d have to pay more than $300 for 40,000mcg of methyl B12. I can sell it for $135, shipping included ;) The savings quickly add up if you’re one of the many with B12 deficiency who need to inject monthly for life.
Frequently Asked Questions
How long does it take for the vitamin B12 supplement to arrive?
About a week or two. While you’re waiting for it, go visit a pharmacy and buy 10ml of sterile saline (NaCl 0.9%) , alcohol swabs, and a pack of insulin syringes (0.3 or 0.5ml). Don’t worry, it’s just a few dollars. Eventually it will look like this:
How much B12 supplement should I take?
Unlike most vitamins, you can’t overdose on B12 and it doesn’t build toxicity. It has been used in ultra-high doses to treat cyanide poisoning, peripheral neuropathy, and even to prolong survival of ALS patients. When I say ultra-high doses, I mean it: 25,000 to 50,000mcg twice a week!
Of course, you don’t need that much.
The secret is little and often. Knowledge in B12 among doctors is scarce, and they normally recommend one shot every month or more. That is not nearly enough. To avoid deteriorating and your symptoms return, aim for little and often — daily, if deficiency is severe.
When you dissolve our 40,000mcg methylcobalamin supplement in 10ml of saline, you get 20 shots of 2,000mcg with 0.5ml syringes, or 33 shots of 1,200mcg with 0.3ml syringes. I prefer the latter, since 2,000mcg per shot is a lot and probably not wholly absorbed.
So, in my opinion, you’ll probably get a better ratio of absorbed B12 per dollar if you just inject daily 1,200mcg shots (0.3ml syringes). This is in my opinion our best B12 supplement dosage. And it’s still a lot — the amount of B12 you’ll find in 250 steaks! It’s also a nice number, because it means you’ll finish each vial in about exactly a month.
Been on daily injections for about 3 months now; he ditched the wheelchair, ditched the walker, and rarely use his cane anymore. Still has some unrepaired nerve damage in one foot, which results in a slight limp, but he’s 90% better. Goes for walks, rides bike. An interesting bonus is that the methylcobalamin enhances mood, gives energy, and helps with depression — he notices the difference in just a couple hours.
How long am I going to need to supplement with B12?
As a rule of thumb, you should keep injecting daily until your symptoms disappear. The numbers on your blood test can be deceiving, because we care about the B12 in your cells, not the bloodstream.
Those with neurological symptoms could need to inject B12 for life. Nerve damage takes a lot of time to heal, if at all. By injecting daily methylcobalamin, at least you know you’re stopping deterioration.
Knowing why you’re deficient is also important. If you can’t absorb B12 from food, you’ll need injections for life. Whatever case, remember that your goal now should be to fill up your cellular stores of B12 as fast as possible, before your nerves are irreversibly damaged.
Once your symptoms begin to fade, you may decrease your B12 supplement frequency from daily to weekly/monthly, or stop altogether if you’re one of the deficient minority who can actually absorb B12 through the stomach.
How much saline do I need for your B12 supplement?
10ml, which is the maximum amount the vial can hold.
By the way, some salines are sold with a “non-injectable” label. This is because for brands to have the “injectable” label, they must go through an endotoxin test using an LAL assay, which is expensive. Many brands just skip this. Try to get saline without the “non-injectable” label if you really care, but personally I don’t mind and have always used any sterile saline.
Is injecting painful?
Not at all. I self injected many times, and I am a skinny guy. If you have a lot of fat, you’ll feel nothing at all. When you think of painful injections, you probably think of intramuscular vaccines. This is far from it. Subcutaneous injections are nothing to be afraid of and give little to no pain.
I’m one of those people that still wants to cry “a little” lol when I know I’m getting a shot, I know!!! But today I gave myself the first B12 injection on my thigh and did not feel it!!!
Is it safe? What are your vitamin B12 supplement side effects?
B12 is one of the safest supplements you can have. It is a water-soluble vitamin, so any excess goes out with the urine. It is non-toxic even in extremely high doses. There are two caveats:
If you’re allergic to methylcobalamin or cobalt, avoid this supplement. That is extremely rare (I’ve never heard of anybody who suffers from it, but I know it exists). To test if you’re allergic, you can administer a small test dose and see if you experience any allergic reaction such as skin rash, face swelling, itching, or anything unusual. You can ask your doctor for help.
If you have Leber’s disease (early hereditary optic nerve atrophy), methylcobalamin is not the best B12 supplement for you. Hydroxy B12 shots, though not as efficient as methyl B12, are safer in that case, because Leber’s disease can get worse in patients with high methylcobalamin levels.
Again, those are very extreme and rare cases. In general, as Dr. Brent Bauer from Mayo Clinic said, “In the complementary medicine realm B12 is probably one of the safest things you could take.”
Is it hard to self-inject your methyl B12 supplement?
Not at all. I’ll send you a one-page instructions on how to prepare and inject subcutaneously at home. It’s very easy, and very safe.
Can I inhale your B12 supplement instead of injecting?
Some people reported vaping methylcobalamin using an e-cigarette delivery device was as efficient as injecting it. I don’t recommend it. Methylcobalamin is an extremely large molecule with a molar mass of 1344.40 g/mol. It would be very unwise to introduce this into delicate lung tissue.
And what about DMSO?
If you don’t know what DMSO means, forget you read it. If you do consider using DMSO instead of injecting, I recommend not to. Injecting subcutaneously is superior and much safer.
Do you also offer an adenosylcobalamin B12 supplement?
No. Methylcobalamin is the easiest to assimilate and addresses a variety of B12 deficiency problems, including providing the methyl group that couples to carbon monoxide (derived from CO2) to afford acetyl-CoA. Methyl B12 is also required for the re-methylation pathway to regain its normal activity, bringing homocysteine down to reasonable levels. It’s the best all-around form, and gives you the most B12 benefits.
What about cyanocobalamin?
Cyanocobalamin is a cheap, synthetic, and slightly toxic form of B12. To use it, your body needs to waste precious methyl groups (which tend to be in short supply) to get rid of the cyanide ligand from it. It then has to convert it into an active form, and many people have ailments that prevent that. It’s not nearly as effective as methylcobalamin, and is completely unnatural to humans.
Methylcobalamin is the form of B12 you’ll find in natural foods. It is much more absorbable, and has a methyl molecule attached to it. So while cyanocobalamin steals existing methyl groups, methylcobalamin provides fresh ones. This is why people with methylation issues improve on methyl B12 but deteriorate on synthetic B12 like cyano or hydroxy.
Methylcoabalmin is really the only treatment you should consider if you suffer neurological symptoms. It bypasses several problematic steps in the absorption cycle, and it’s why Japan uses it almost exclusively.
Is there an expiration date?
Each vial has an expiration date of a little less than year. Don’t worry, you’re probably going to finish it in a month though.
What’s the best way to store your vitamin B12 supplement?
B12 is always stable when in dry (powder) form. When you dissolve it in saline though, it undergoes photolysis (destruction by light). Our vials are made of Amber glass (best one there is), which prevents 2/3 of the light from coming in. To get rid of the other 1/3, cover the vial with an aluminum foil. Store the vial in 5-25°C (41-77°F). Fridge is good.
Can I just take this supplement orally?
Only a minority of patients responds clinically to oral therapy. This is because most deficient people have issues absorbing B12 through the stomach. Most patients recover much faster by injecting B12 rather than trying to digest it (food, tablets, etc). B12 injections are always the best way to rapidly get your B12 levels back to normal and avoid permanent neurological damage.
Can’t I just buy B12 shots over the counter?
In some countries you can. But unless you’re from Japan (one of the leaders of B12 research), it’s probably made of synthetic cyanocobalamin or hydroxycobalamin. Methylcobalamin is much more effective.
I’m looking for a vegan B12 supplement! Is it vegan?
Should I change my diet when I take your vitamin B12 supplement?
You may want to increase your potassium intake. Good sources are salmon, leafy greens like spinach and kale, avocado, banana, and baked potato/sweet potato (careful if you’re diabetic) with the skin on.
Also, if your blood tests indicate you’re not on the upper range of folate, consider taking an l-methylfolate supplement (much more effective than folic acid). B12 and folate (B9) need each other.
Need any help?
When I say this is the best vitamin b12 supplement out there, I mean it. If you have any question or anything, contact me.